One excellent option is the transpeninsular route in Baja California.

The breathtaking views of the largest cactus sanctuary in the world; they contrast with the beauty of the intense blue of the Sea of Cortez, which Jacques Cousteau called the “aquarium of the world”, thanks to the variety of marine ecosystems, particularly in the Cabo Pulmo Reserve.
The vineyards and the good gastronomy is another of the great attractions of the region.